Interoperability across data sets is a key challenge for quantitative histopathological imaging. There is a need for an ontology that can support effective merging of pathological image data with associated clinical and demographic data. To foster organized, cross-disciplinary, information-driven collaborations in the pathological imaging field, we propose to develop an ontology to represent imaging data and methods used in pathological imaging and analysis, and call it Quantitative Histopathological Imaging Ontology – QHIO. We apply QHIO to breast cancer hot-spot detection with (...) the goal of enhancing reliability of detection by promoting the sharing of data between image analysts. (shrink)

Well-organized and highly readable Sex and Gender: The Human Experience provides a current, multicultural analysis of gender-related issues, theories, and research. The authors' clear presentation of the perspectives and issues related to sex and gender studies enables students to easily comprehend the material. Further, a highly practical approach prompts students to examine their self-awareness and social tolerance. Sex and Gender: The Human Experience is appropriate as a primary or supplementary text in Psychology, Family Studies, or Women's Studies curricula.

The topics covered in this volume, originally published in 1973, include the need for a more adequate concept or definition of education, the issue of whether indoctrination is compatible with education, particularly with moral education, and the processes of judging the merits of different approaches to aesthetic education. Two contributors present complementary analyses of the relations between freedom as a characteristic of institutions and the process of learning to be a free man. There is discussion of the neglected subject of (...) rights and duties in education, with special emphasis on the question of a universal right to education. The volume concludes with papers on the relevance of philosophy to the practical judgments of educators and to education as a field of study. (shrink)

The topics covered in this volume, originally published in 1973, include the need for a more adequate concept or definition of education, the issue of whether indoctrination is compatible with education, particularly with moral education, and the processes of judging the merits of different approaches to aesthetic education. Two contributors present complementary analyses of the relations between freedom as a characteristic of institutions and the process of learning to be a free man. There is discussion of the neglected subject of (...) rights and duties in education, with special emphasis on the question of a universal right to education. The volume concludes with papers on the relevance of philosophy to the practical judgments of educators and to education as a field of study. (shrink)

It is becoming increasingly apparent that Elizabeth Anscombe, long known as a student, friend and translator of Wittgenstein, was herself one of the most important philosophers of the twentieth century. No Morality, No Self examines her two best-known papers, in which she advanced her most amazing theses. In 'Modern Moral Philosophy', she claimed that the term moral, understood as picking out a special, sui generis category, is literally senseless and should therefore be abandoned. In 'The First Person', she maintained that (...) the word 'I' is not a referring expression: in other words, its function in the language is not to pick out the speaker, or 'the self' - or any entity whatsoever. Both papers are considered influential, and are frequently cited; but their main claims, and many of their arguments, have been widely misunderstood. In this book James Doyle shows that once various errors of interpretation have been cleared away, the claims can be seen to be far more plausible, and the arguments far more compelling, than even her defenders have realized. Philosophers often seek attention by making startling claims which are subsequently revealed as little more than commonplaces wrapped in hyperbole. Doyle's book makes it clear that here, in her greatest papers, Anscombe achieves something vanishingly rare in philosophy: a persuasive case for genuinely unsettling and profound conclusions. The two lines of argument, seemingly so disparate, are also shown to be connected by Anscombe's deep opposition to the Cartesian picture of the mind.--. (shrink)

Virtue and the Moral Life brings together distinguished philosophers and theologians with younger scholars of consummate promise to produce ten essays that engage both academics and students of ethics. This collection explores the role virtues play in identifying the good life and the good society.

This portrait of Hume as an ironist is offered as a supplement to recent historical and biographical studies, and especially to Mossner's The Life o] David Hume. While others have commented on the irony in Hume's writings, Price goes further and suggests that irony is a key with which to unlock Hume's philosophical attitudes and beliefs. Since ap- preciation of irony depends on an awareness of context, Price interprets this to mean that Hume's writings must be read against the background (...) of his life and intellectual milieu. He traces the development of Hume's use of irony through four successive stages, beginning with the formative influences on the early writings and concluding with the culmination of Hume's ironic style in the last works -- principally the Dialogues Concerning Natural Religion. (shrink)

Moral rationalism is identified as the view that moral constraints are rational constraints. This view seems implausible to many because it seems to involve belief in the fantastic-sounding possibility of egoist-conversion: that, in principle, an argument for moral constraints could be produced which would motivate a rational person who does not yet accept those constraints to observe them. Furthermore, the Humean want-belief model of motivation---the view that beliefs alone are incapable of motivating---seems to provide a good explanation for the impossibility (...) of egoist-conversion. I argue that the moral rationalist is not in fact committed to the possibility of egoist-conversion, and that an explanation of its impossibility can be given which is compatible with rationalism; so this impossibility counts neither against rationalism nor for the want-belief model. I consider a number of apparent objections to my position and rebut them. (shrink)

I here adapt some ideas of Prior’s 1967 paper ‘On spurious egocentricity’ in the interest of seeing how much sense can be made of the doctrine that ‘I’ is not a referring-expression. I suggest how an account of ‘I’ might draw upon both Prior’s treatment of the operator ‘I believe that’ and of operators like ‘it is true that’ and ‘it is now the case that’, which Prior argues are logically very different from ‘I believe that’. In the final section (...) I present some objections to Prior’s account of ‘now’, and try to give a more adequate account of the analogy between ‘now’ and ‘I’. (shrink)

T he Question of punishment and its justification has been a major preoccupation in recent philosophy of law. The reasons for this growing concern are not difficult to discover. Both philosophers and jurists have become increasingly sceptical of traditional theories of legal punishment. Each of these inherited theories was designed to establish criteria for the recognition and appraisal of punishment as a legal institution. However, alternative theories emphasised different and often conflicting criteria. Some theories emphasised moral desert and retribution, while (...) others appealed to the social utilities of punishment. Failure to reconcile these diverse philosophical viewpoints, through sustained debate over two centuries, has been a major source of intellectual dissatisfaction. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews St. Auc~stine and Being: A Me$aphyM,cal Essay. By James F. Anderson. (The Hague: Martinus Nijhoff, 1965.Pp. viii [i] + 76. Guilders 9.90.) Contemporary students of medieval philosophy, especially those influenced by the writings of Gilson, usually view Augustine as primarily an essentialist in metaphysics, while Aquinas is viewed as some sort of existentialist. This is taken to mean that, whereas Augustine seems to identify being with (...) essence or wha~ a thing is, Aquinas distinguishes between what a thing is and its act of existence. The major contribution of Aquinas to later philosophy is often depicted as this distinction between essence and existence. Perhaps the major interest and value of Professor Anderson's essay is that it contests this currently predominant opinion of the essentialist character of Augustinian metaphysics and calls for a re-evaluation of the supposedly revohi~ionary character of the Thomistic concentration upon the act of existence. It is quite evident that Augustine broke with Plotinus when he asserted that the first principle of all things was God, being itself (ipsum esse), rather than the One, which transcends being. The controversy arises over Augustine's view of the nature of being (esse). For Gilson the notion of being remained for Augustine Neoplatonic, while for Anderson Augustine introduced an existential aspect to the notion of being lacking in Neoplatonic thought. Citing the same texts for support Gilson maintains that Augustine interprets the name of God given in Exodus as "I am he who never changes," while Anderson maintains that Augustine interprets Exodus as asserting that God is being, in the sense of existence, itself. The major point of disagreement between Gilson and Anderson is not whether Augustine regarded being as pre~ dominant, but how Augustine interpreted the notion of being. In some texts Augustine maintsSns that being and immutability mean the same thing, in others he argues that a thing truly is 'because it is immutable, and in yet others he argues that a thing is immutable because it truly is. The first opinion seems to be the one frequently favored as an interpretation of Augustine by Gilson. The second is usually regarded as Neoplatonic. The third is the opinion which Professor Anderson argues was most accurately Augustine's. According to Professor Anderson the first two opinions reflect for Augustine a merely factual connection between being and immutability, whereas the third reflects a metaphysical entailment. I should like to mention three points in Professor Anderson's discussion which seem to me weak. Firstly, as Augustine remarks that being is the name for unchangeableness we cannot take this as asserting a merely factual relationship. Secondly, to say that 'being' and 'immutability ~mean the same thing to Augustine or that being and immutability are identical to him does not necessitate, as Professor Andersen claims, denying the primacy of being. If 'being' and 'immutability' mean the same thing, then it is very peculiar to ask which is primary. If it is remarked that 'triangleI means the same thing as 'three sided figure', what sense does it make to ask which notion is primary? I suspect that Professor Anderson's contention makes sense only if one believes that there is a difference in the meanings of 'being' and 'immutability ', but whether or not there was such a difference for Augustine is precisely the point at issue. Professor Anderson asserts that it would be a "metaphysical inconsistency" to claim that God is both being and immutability, but it is not clear why such a claim would be inconsistent if the two terms in fact mean the same thing (p. 30). Thirdly, if, as is in fact the case, Augustine's remarks on the relationship between immutability and being are inconsistent perhaps we should accept the possibility that Augustine himself never came to a clear view on this matter rather than attempt to surmise what Augustine "must have meant." Of course, such inconsistency in Augustine's writings would tend to support the thesis of Gilson that Augustine has difficulties reconciling his theology and metaphysics. Moreover, the analogy Professor Anderson suggests between the Augustinian mutability-immutability contrast and the Thomistic potency-act contrast could only be a very rough one... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews St. Auc~stine and Being: A Me$aphyM,cal Essay. By James F. Anderson. (The Hague: Martinus Nijhoff, 1965.Pp. viii [i] + 76. Guilders 9.90.) Contemporary students of medieval philosophy, especially those influenced by the writings of Gilson, usually view Augustine as primarily an essentialist in metaphysics, while Aquinas is viewed as some sort of existentialist. This is taken to mean that, whereas Augustine seems to identify being with (...) essence or wha~ a thing is, Aquinas distinguishes between what a thing is and its act of existence. The major contribution of Aquinas to later philosophy is often depicted as this distinction between essence and existence. Perhaps the major interest and value of Professor Anderson's essay is that it contests this currently predominant opinion of the essentialist character of Augustinian metaphysics and calls for a re-evaluation of the supposedly revohi~ionary character of the Thomistic concentration upon the act of existence. It is quite evident that Augustine broke with Plotinus when he asserted that the first principle of all things was God, being itself (ipsum esse), rather than the One, which transcends being. The controversy arises over Augustine's view of the nature of being (esse). For Gilson the notion of being remained for Augustine Neoplatonic, while for Anderson Augustine introduced an existential aspect to the notion of being lacking in Neoplatonic thought. Citing the same texts for support Gilson maintains that Augustine interprets the name of God given in Exodus as "I am he who never changes," while Anderson maintains that Augustine interprets Exodus as asserting that God is being, in the sense of existence, itself. The major point of disagreement between Gilson and Anderson is not whether Augustine regarded being as pre~ dominant, but how Augustine interpreted the notion of being. In some texts Augustine maintsSns that being and immutability mean the same thing, in others he argues that a thing truly is 'because it is immutable, and in yet others he argues that a thing is immutable because it truly is. The first opinion seems to be the one frequently favored as an interpretation of Augustine by Gilson. The second is usually regarded as Neoplatonic. The third is the opinion which Professor Anderson argues was most accurately Augustine's. According to Professor Anderson the first two opinions reflect for Augustine a merely factual connection between being and immutability, whereas the third reflects a metaphysical entailment. I should like to mention three points in Professor Anderson's discussion which seem to me weak. Firstly, as Augustine remarks that being is the name for unchangeableness we cannot take this as asserting a merely factual relationship. Secondly, to say that 'being' and 'immutability ~mean the same thing to Augustine or that being and immutability are identical to him does not necessitate, as Professor Andersen claims, denying the primacy of being. If 'being' and 'immutability' mean the same thing, then it is very peculiar to ask which is primary. If it is remarked that 'triangleI means the same thing as 'three sided figure', what sense does it make to ask which notion is primary? I suspect that Professor Anderson's contention makes sense only if one believes that there is a difference in the meanings of 'being' and 'immutability ', but whether or not there was such a difference for Augustine is precisely the point at issue. Professor Anderson asserts that it would be a "metaphysical inconsistency" to claim that God is both being and immutability, but it is not clear why such a claim would be inconsistent if the two terms in fact mean the same thing (p. 30). Thirdly, if, as is in fact the case, Augustine's remarks on the relationship between immutability and being are inconsistent perhaps we should accept the possibility that Augustine himself never came to a clear view on this matter rather than attempt to surmise what Augustine "must have meant." Of course, such inconsistency in Augustine's writings would tend to support the thesis of Gilson that Augustine has difficulties reconciling his theology and metaphysics. Moreover, the analogy Professor Anderson suggests between the Augustinian mutability-immutability contrast and the Thomistic potency-act contrast could only be a very rough one... (shrink)

Ontology is one strategy for promoting interoperability of heterogeneous data through consistent tagging. An ontology is a controlled structured vocabulary consisting of general terms (such as “cell” or “image” or “tissue” or “microscope”) that form the basis for such tagging. These terms are designed to represent the types of entities in the domain of reality that the ontology has been devised to capture; the terms are provided with logical defi nitions thereby also supporting reasoning over the tagged data. Aim: This (...) paper provides a survey of the biomedical imaging ontologies that have been developed thus far. It outlines the challenges, particularly faced by ontologies in the fields of histopathological imaging and image analysis, and suggests a strategy for addressing these challenges in the example domain of quantitative histopathology imaging. The ultimate goal is to support the multiscale understanding of disease that comes from using interoperable ontologies to integrate imaging data with clinical and genomics data. (shrink)

Research into two-stage models of “free will” – first “free” random generation of alternative possibilities, followed by “willed” adequately determined decisions consistent with character, values, and desires – suggests that William James was in 1884 the first of a dozen philosophers and scientists to propose such a two-stage model for free will. We review the later work to establish James’s priority. By limiting chance to the generation of alternative possibilities, James was the first to overcome the standard (...) two-part argument against free will, i.e., that the will is either determined or random. James gave it elements of both, to establish freedom but preserve responsibility. We show that James was influenced by Darwin’s model of natural selection, as were most recent thinkers with a two-stage model. In view of James’s famous decision to make his first act of freedom a choice to believe that his will is free, it is most fitting to celebrate James’s priority in the free will debates by naming the two-stage model – first chance, then choice -“Jamesian” free will. (shrink)

On the surface, the Doyles are the archetypal happy Irish family, loving, secureand tradtional. They all have their small rebellions, but somehow power remains in the hands of Mr Doyle, a benign patriarch controlling all their lives. But, in the world outside, the old order is being dismantled and the traditional roles the Doyles have always accepted are finally being challenged. Right at the heart of the Doyle household, threatening their own miniature household, sits a revelation that will (...) throw them unwillingly and inexorably into conflict. (shrink)

I argue that there is nothing wrong with perfect voyeurism , covert watching or listening that is neither discovered nor publicized. After a brief discussion of privacy I present attempts from Stanley Benn, Daniel Nathan, and James Moor to show that the act is wrong. I argue that these authors fail to make their case. However, I maintain that, if detected or publicized, voyeurism can do grave harm and to that extent should be severely punished. I conclude with some (...) thoughts on the stubborn intuition that perfect voyeurism is wrong despite the absence of harm. (shrink)

Anna Doyle Wheeler was a nineteenth‐century, Irish‐born socialist and feminist. She and another Irish‐born socialist and feminist, William Thompson, produced a book‐length critique in 1825, Appeal of One Half the Human Race, Women: Against the Pretensions of the Other Half, Men, to Retain Them in Political, and Thence in Civil and Domestic, Slavery: In Reply to a Paragraph of Mr. Mill's Celebrated “Article on Government,” to refute the claims of liberal philosopher James Mill in 1820 that women did (...) not need to be enfranchised. In so doing the Appeal undermined the philosophical credibility of Mill's liberal utilitarianism. The Appeal exposed the hypocrisy of the language of contract (whether social, sexual, or marriage) by showing that men's freedom and claims to rights presupposed the unfreedom and sexual subjugation of women. The article argues that the Appeal was an original formulation of feminist political theory that still retains its relevance in the twenty‐first century. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Conscience and Calling: Ethical Reflections on Catholic Women's Church Vocations by Anne E. PatrickMary M. Doyle RocheConscience and Calling: Ethical Reflections on Catholic Women's Church Vocations Anne E. Patrick NEW YORK AND LONDON: BLOOMSBURY T&T CLARK, 2013. 197 PP. $24.95In Conscience and Calling, Anne Patrick weaves together insights into women's moral agency, vocational discernment, and historical narratives of religious women's engagement with clerical authority. Taking up (...) class='Hi'>James Gustafson's question, "What is God enabling and requiring us to be and to do?" she offers a nuanced view of virtuous discernment and action in the context of the "ecclesial oppression" of women. Patrick asks, "What is correct 'church practice' for female moral agents in view of the institutionalized injustice toward women in Catholicism?" (59).Chapter 1 begins with cases of conflict between women's religious congregations and clerical leadership. In the first case, Sisters of the Holy Names of Jesus and Mary protested intolerable living conditions at a parish in Brooklyn, New [End Page 201] York, in 1939. When repeated requests for heat fell on the pastor's deaf ears, the sisters requested to leave the parish and were told that they would then also have to leave another thriving ministry in the diocese. The sisters acquiesced to this decision in a spirit of obedience and did not publicize the real reason for their departure. Fifty years later in Miami, Florida, when another conflict arose, the sisters involved discerned a very different response to injustice, one marked by concern for "justice, honesty, and personal responsibility." The model of a "good sister" had shifted from an emphasis on obedience and institutional loyalty toward shared responsibility for ministry and leadership.Chapter 2 surveys the landscape of women's engagement with the Church and its structures of leadership and adapts H. Richard Niebuhr's Christ and Culture to sketch five "types": women against the Church; women content with the Church; women above the Church; women and Church in paradox; and women transforming Church. Patrick proposes the transformationist model as the approach that most adequately meets the challenges that women face in the Church today; she calls on those who adopt this approach to live in creative tension with the Church and with those who follow the other models, to espouse justice and mutuality in organizational structures, and to be self-critical. Chapter 3 recounts the history of the National Assembly of Religious Women through this transformational lens.Chapter 4 proposes a "framework for love" that builds on Margaret Farley's ethic of commitment to envision an ethic of vocation that elicits "active receptivity," values the contributions of institutions, practices egalitarianism, and keeps justice and love in dialectical relationship. The "myth" of vocation (the notion that vocation is a "thing" to be discovered and pursued, like one's destiny or soul mate) is balanced by the "mystery" of vocation that engages ongoing, lifelong discernment. Controversial cases involving women religious illustrate this kind of discernment and women's striving to live justly and faithfully. The final chapter, "Vocation in a Transformed Social Context," recounts the Vatican Congregation for the Doctrine of the Faith's visitation of the Leadership Conference of Women Religious, a case that has changed the landscape for women's discernment once again. Patrick calls the Church to live out its rhetorical commitment to the dignity of women by opening all church ministries so that women might serve and lead.Conscience and Calling tells an important story about how women religious have discerned the signs of the times and imagined new vocations in the Church and the world. Though the focus here is on women in the American Catholic Church, Patrick's contribution should pave the way for sharing religious women's stories in the global context to further enrich a Christian vision of virtue and vocation for those navigating ecclesial politics and practicing ministry in particular. [End Page 202]Mary M. Doyle RocheCollege of the Holy CrossCopyright © 2017 Society of Christian Ethics... (shrink)

If I choose two words in the book that I think have been most influential, I would choose "mutually exclusive." Sacks was scarcely the first critic to observe that the kinds of fiction are usually actions, apologues, or satires. But no other theoretician has insisted so cogently as he did that, as principles governing the interaction of parts in a coherent work, these principles are mutually exclusive, "mutually incompatible." The reason Sacks became a great journal editor was that the firmness (...) of his own principles never blinded him to the value of other and very different theoretical questions which might be addressed to a work of fiction. And his tone of voice was never brazen but always that of the eighteenth-century gentleman: Come, let us reason together. Yet he never blinked his adherence to the truths he saw: he stated them directly, and he taught us to strive equally to face the consequences of holistic recognition of forms: "One cannot create an action which is also a satire any more than he can write an active sentence which is also a passive sentence in English. To carry the analogy a step farther, the observation that the types are mutually incompatible is no more an attempt to dictate to writers what they may or may not do than is the observation that active sentences are not passive sentences" . Mary Doyle Springer, associate professor of English at Saint Mary's College of California, is the author of Forms of the Modern Novella and A Rhetoric of Literary Character: Some Women of Henry James. She is presently at work on a companion theoretical study dealing with the rhetoric of dramatic character in performance. (shrink)

In this paper we explain our pretense account of truth-talk and apply it in a diagnosis and treatment of the Liar Paradox. We begin by assuming that some form of deflationism is the correct approach to the topic of truth. We then briefly motivate the idea that all T-deflationists should endorse a fictionalist view of truth-talk, and, after distinguishing pretense-involving fictionalism (PIF) from error- theoretic fictionalism (ETF), explain the merits of the former over the latter. After presenting the basic framework (...) of our PIF account of truth-talk, we demonstrate a few advantages it offers over T-deflationist accounts that do not explicitly acknowledge pretense at work in the discourse. In turning to the Liar Paradox, we explain how the quasi-anaphoric functioning that our account attributes to truth-talk provides a diagnosis of the Liar Paradox (and other instances of semantic pathology) as having no content—in the sense of not specifying any of what we call M-conditions. At the same time, however, we vindicate the intuition that we can understand liar sentences, thereby avoiding one standard objection to “meaningless strategy” responses to the Liar Paradox. With this diagnosis in place, we then, by way of treatment, introduce a new predicate, ‘semantically defective’, and show how the explanation we give for its application allows for a consistent, yet revenge-immune, (dis)solution of the Liar Paradox, and semantic pathology generally. (shrink)

The eighteenth century was a time of brilliant philosophical innovation in Britain. In Of Liberty and Necessity James A. Harris presents the first comprehensive account of the period's discussion of what remains a central problem of philosophy, the question of the freedom of the will. He offers new interpretations of contributions to the free will debate made by canonical figures such as Locke, Hume, Edwards, and Reid, and also discusses in detail the arguments of some less familiar writers. Harris (...) puts the eighteenth-century debate about the will and its freedom in the context of the period's concern with applying what Hume calls the "experimental method of reasoning" to the human mind. His book will be of substantial interest to historians of philosophy and anyone concerned with the free will problem. (shrink)

A variety of approaches have appeared in academic literature and in design practice representing “ethics-first” methods. These approaches typically focus on clarifying the normative dimensions of design, or outlining strategies for explicitly incorporating values into design. While this body of literature has developed considerably over the last 20 years, two themes central to the endeavour of ethics and values in design (E + VID) have yet to be systematically discussed in relation to each other: (a) designer agency, and (b) the (...) strength of normative claims informing the design process. To address this gap, we undertook a structured review of leading E + VID approaches and critiques, and classified them according to their positions on normative strength, and views regarding designer agency. We identified 18 distinct approaches and 13 critiques that met the inclusion criteria for our review. Included papers were distributed across the spectrum of views regarding normative strength, and we found that no approaches and only one critique represented a view characteristic of “low” designer agency. We suggest that the absence of “low” designer agency approaches results in the neglect of crucial influences on design as targets of intervention by designers. We conclude with suggestions for future research that might illuminate strategies to achieve ethical design in information mature societies, and argue that without attending to the tensions raised by balancing normatively “strong” visions of the future with limitations imposed on designer agency in corporate-driven design settings, “meaningful” ethical design will continue to encounter challenges in practice. (shrink)

Descriptions of how managers think about the moral questions that come up in their work lives are analyzed to draw out the moral assumptions to which they commonly refer. The moral standards thus derived are identified as (1) honesty in communication, (2) fair treatment, (3) special consideration, (4) fair competition, (5) organizational responsibility, (6) corporate social responsibility, and, (7) respect for law. It is observed that these normative standards assume the cultural form of social conventions but because managers invoke them (...) as largely private intuitions, their cultural status remains precarious and unclear. This is the second in a research series of three papers. (shrink)

How different neural crest derivatives differentiate in distinct embryonic locations in the vertebrate embryo is an intriguing issue. Many attempts have been made to understand the underlying mechanism of specific pathway choices made by migrating neural crest cells. In this speculative review we suggest a new mechanism for the regulation of neural crest cell migration patterns in avian and mammalian embryos, based on recent progress in understanding the expression and activity of receptor tyrosine kinases during embryogenesis. Distinct subpopulations of crest‐derived (...) cells express specific receptor tyrosine kinases while residing in a migration staging area. We postulate that the differential expression of receptor tyrosine kinases by specific subpopulations of neural crest cells allows them to respond to localized growth factor ligand activity in the embryo. Thus, the migration pathway taken by neural crest subpopulations is determined by their receptor tyrosine kinase response to the differential localization of their cognate ligand. (shrink)

Introduction -- "Mediating estrangement: a theory for diplomacy," review of International Studies (April, l987), 13, pp. 91-110 -- "Arms, hostages and the importance of shredding in earnest: reading the national security culture," Social Text (Spring, 1989), 22, pp. 79-91 -- "The (s)pace of international relations: simulation, surveillance and speed," International Studies Quarterly (September 1990), pp. 295-310 -- "Narco-terrorism at home and abroad," Radical America (December 1991), vol. 23, nos. 2-3, pp. 21-26 -- "The terrorist discourse: signs, states, and systems of (...) global political violence," World Security: Trends and Challenges at Century's End, ed. M. Klare and D. Thomas, St. Martin's Press (1991), pp. 237-265. -- "S/N: international theory, balkanisation, and the new world order," Millennium Journal for International Studies (Winter 1991), vol. 20, no. 3, pp. 485-506 -- "Cyberwar, videogames, and the Gulf War syndrome," Antidiplomacy: Spies, Terror, Speed and War (Cambridge, Ma and Oxford, UK, 1992), pp. 173-202 -- "Act IV: fathers (and sons), mother courage (and her children), and the dog, the cave, and the beef," in Global Voices: Dialogues in International Relations, ed. James N. Rosenau (Boulder, Co and Oxford, Uk: Westview Press, 1993), pp. 83-96 -- "The value of security: Hobbes, Marx, Nietzsche and Baudrillard," in the Political Subject of Violence, ed. G.M. Dillon and David Campbell, Manchester University Press (1993), pp. 94-113 -- "The C.I.A., Hollywood, and sovereign conspiracies," Queen's Quarterly (Summer 1993), vol. 100, no. 2, pp. 329-347 -- "Great men, monumental history, and not-so-grand theory: a meta-review of Henry Kissinger's diplomacy," Forum review article, Mershon International Studies Review (april 1995), vol. 39, no. 1, pp. 173-180 -- "Post-theory: the eternal return of ethics in international relations," New Thinking in International Relations Theory, eds. Michael Doyle and John Ikenberry (New York: Westview Press, 1997), pp. 55-75 -- "Cyber-deterrence," Wired (September 1994), 2.09., p. 116 (plus 7 pages) -- "Global swarming, virtual security, and Bosnia," the Washington Quarterly (Summer 1996), vol. 19, n0. 3., pp. 45- 56 -- "The simulation triangle," 21c (issue 24, 1997), pp. 19-25 -- "Virtuous war and hollywood," the Nation (3 april 2000), pp. 41-44 -- "Virtuous war/virtual theory," International Affairs (fall, 2000), pp. 771-788 -- "Hedley Bull and the case for a post-classical approach," International Relations at LSE: a History of 75 Years (London: Millennium Publishing Group, 2003), pp. 61-87. "the illusion of a grand strategy, op-ed," the New york Times, may 25, 2001 -- "In terrorem: before and after 9/11," Worlds in Collision, eds. Ken Booth and Tim Dunne (New York: Palgrave Macmillan, 2002), pp. 101-116 -- "The question of information technology in international relations," Millennium Journal of International Studies (vol. 32, no. 3, 2003), pp. 441-456 -- "The illusion of a grand strategy," op-ed, the New York Times, may 25, 2001. (shrink)

For at least the past several decades, medicine has been embroiled in a crisis concerning the nature of its professionalism. The fundamental questions that drive this ongoing crisis are primarily three. First, what is the nature of medical professionalism? Second, who are medical professionals? Third, what does medicine or these professionals profess or promise? In this paper, the professionalism crisis vis-à-vis these questions is examined and analyzed chiefly in terms of both Francis Peabody’s and Edmund Pellegrino’s writings. Based on their (...) writings, I introduce a conceptual framework for professionalism to address the crisis. In addition, I contend that to address the professionalism crisis adequately, medicine’s position within an evolving health care network must also be considered. To that end, I first discuss the genesis of the crisis in terms of the Flexner Report and especially Peabody’s response to it. Next, I explore how the crisis intensified during the twentieth century, particularly in terms of medicine’s ultimate scientification and eventual commercialization, and how Pellegrino reacted to this. I then propose a health care professionalism cycle and a care-competence cycle to provide a conceptual framework for addressing the crisis. I conclude that medicine’s position is no longer as the center of health care but rather as another node within a wider evolving health care network. And the resolution of medicine’s professionalism crisis depends on medicine’s positioning and defining itself in terms of the professionalism for each of the other professions within the health care network. (shrink)

This article details philosophical responses to the problem posed by the existence, whether real or perceived, of priestcraft, a problem that boiled down to a fear that if the custodians of God’s tabernacle were corrupt, so too were the contents of the tabernacle. It first explores the attempts of Edward Herbert and Thomas Hobbes to guarantee the truth of revealed matters of faith in response to their perception of widespread priestcraft, arguing that, while each sought to undermine sacerdotal authority, they (...) ultimately exempted matters of faith from the litmus test of reason. This resulted in a less-than-satisfactory solution to the problem. It turns next to Locke’s Essay (1690) and The Reasonableness of Christianity (1695), exploring how empirical notions of evidence, fact, and probability, as framed in these works, enabled a radical re-evaluation of the grounds of Christian faith, which subsequently influenced the writings of John Toland, Anthony Collins, and Peter Annet between the 1690s and 1740s. These “Lockean free-thinkers,” it argues, were in fact closer to the position of the Essay and Reasonableness than to the deism of Edward Herbert in their efforts to tackle priestcraft. Concluding, this article proposes that the problem of priestcraft served as a catalyst for early modern British philosophers to increasingly narrow the grounds of faith, until faith was deemed legitimate only when grounded upon fact. (shrink)

Purity violations overlap with other moral domains. They are not uniquely characterized by hypothesized markers of purity – the witness's emotion of disgust, taint to perpetrator's soul, or the diminished role of intention in moral judgment. Thus, Fitouchi et al.'s proposition that puritanical morality (a subset of violations in the purity domain) is part of cooperation-based morality is an important advance.

Journal of International Political Theory, Ahead of Print. Joseph Carens develops one of the most prominent cases for open borders in the academic literature on the basis of freedom and equality. Yet the implementation of his social membership theory would mean that immigrants who have not yet lived in a country long enough to become members would be excluded from political and social rights, thus raising the possibility of their domination and subordination by citizens. Given that these problems arise because (...) Carens aims to balance the freedom of individuals with the “claims of belonging” to a political community, can we theorize the relationship between freedom and community differently? French philosopher Jean-Luc Nancy does just that, by showing how to think freedom and community as mutually constitutive. Nancy thus offers the resources for an alternative case for open borders, grounded on the claim that the freedom of community entails openness to the outside. Drawing also on Nancy’s account of the common and of democratic politics, my Nancean argument for open borders challenges Carens’s exclusion of nonmembers from the rights of citizens, emphasizing instead the need for an ongoing political struggle to expand who is eligible to claim rights as well as the scope of the rights themselves. (shrink)

In recent years there has been a major revival of interest in the political philosophy of Immanuel Kant. Thinkers have looked to Kant's theories about knowledge, history, the moral self and autonomy, and nature and aesthetics to seek the foundations of their own political philosophy. This volume, written by established authorities on Kant as well as by new scholars in the field, illuminates the ways in which contemporary thinkers differ regarding Kantian philosophy and Kant's legacy to political and ethical theory. (...) The book contains essays by Patrick Riley, Lewis White Beck, Mary Gregor, and Richard L. Velkley that place Kant in the tradition of political philosophy; chapters by Dieter Henrich, Susan Shell, Michael W. Doyle, and Joseph M. Knippenberg that examine Kantian perspectives on history and politics; contributions by William A. Galston, Bernard Yack, William James Booth, and Ronald Beiner that judge the Kantian legacy; and classic discussions by John Rawls, Jürgen Habermas, Charles Taylor, and Hans-Georg Gadamer that present different perspectives on contemporary debates about Kant. (shrink)

Postmodern critical assessments of Freud’s theory of mourning disavow the idea of grief’s conclusiveness, insisting that mourning is an interminable process or even a transcendental structure of experience. However, such assessments presuppose an ontological orientation toward finitude that avoids the profound speculative implications of the non-finite status of death in the unconscious. In consequence, mourning comes to assume an indefinite, generic status as a condition of experience instead of a resolutely speculative confrontation with the impossible real of infinitude. Freud’s writings (...) evidence his difficulties with this unconscious disjunction of mourning from finitude, but can be elucidated by turning to Hegel’s critical discussion of “infinite grief,” the melancholy apprehension of finitude as a spurious infinity. Hegel’s analysis in turn anticipates Lacan’s elaboration of the death drive as a concept of unconscious transmission. Here, what begins to emerge is a theory of mourning that concerns the speculative inheritance of an immortal object. (shrink)